李建华美女教师,广州医科大学教学,博士运筹帷幄生导师。现任广州医科大学教务处处长、锤真金不怕火教学发展中心主任。曾获广东省南粤优秀训诲使命者、广州市优秀锤真金不怕火、广州市优秀训诲使命者等荣誉名称,获广东省教学着力一、二等奖4项。主抓国度级一流课程1门,广东省一流本科课程2门、课程教研室1个。承担及参与种种教学改换技俩10多项,主抓《心血管生理》东说念主民卫生出书社慕课1门,参编东说念主民卫生出书社出书专著1部,主编和副主编生理学、机能履行学等讲义16部。
科学运筹帷幄场合为呼吸生理,曾承担和参与国度当然基金、省当然基金等国度、省、市、学校的科研技俩10多项,在Nature子刊Cell Death & Disease、好意思国生理学经典杂志Am JPhysiol-cellPh等国表里医学限制泰斗杂志上发表教学科研论文100余篇,获专利授权2项。培养硕士运筹帷幄生15名,多名运筹帷幄生赢得国度奖学金及校级优秀毕业论文奖。先后引诱30多名本科生课外科技举止,赢得课外科技技俩立项12项(国度级2项、省市级3项),发表科研论文7篇,赢得“挑战杯”广东大学生课外学术科技作品竞赛等种种各级奖项6项,引诱20余名本科生完成毕业论文瞎想及答辩。
比年主抓科研技俩
(1)国度当然科学基金-面上技俩,81470205,TRPC6在臭氧致气说念炎症中的作用及硫化氢烦闷,2015.01-2018.12,75万,结题,主抓。
(2)广东省当然科学基金-面上技俩,2021A1515012145,SNAREs调控巨噬细胞外泌体分泌在PM2.5致肺气肿中作用及机制,2021.1.1-2023.12.31,10万,在研,主抓。
(3)广东省当然科学基金-面上技俩,8151018201000039,TRPC在哮喘豚鼠气说念平滑肌细胞增殖中的作用,2009.1-2010.12,5万元美女教师,结题,主抓。
(4)广州市科学本事局,202102080324,巨噬细胞外泌体开头ADAM10在COPD肺气肿中的作用,2021.4.1-2023.3.31,5万,在研,主抓。
(5)广州市属高校科研瞎想要点技俩,A2013246,TRPC6通说念卵白偏执卑劣信号通路在臭氧致气说念炎症中的作用,2013.04-2016.04,10万元,结题,主抓。
(6)广州医科大学学科拓荒经费资助技俩,肺泡巨噬细胞外泌体开头ADAM8在PM2.5致肺气肿中作用及机制,2021.06-2023.05,10万,在研,主抓。
比年主要发表论文 勾引porn
(1)Chen QZ#, Zhou YB#, Zhou LF#, Fu ZD, Yang CT, Zhao L, Li SN, Chen Y, Wu YS, Ling ZW, Wang YF, Huang JR*, Li JH*(通信作家) . TRPC6-dependent Ca2+ signaling mediates airway inflammation in response to oxidative stress via ERK pathway. Cell Death & Disease ,2020, 11(3): 170. (IF=8.469)
(2)Liu G, Xu D, He Y, Xu J, Huang S, Zhang W, Qiu X,Wang X, Li JH*(通信) , Huang J (2021). Inhibition of transient receptor potential canonical 6 attenuates fibroblast-like synoviocytes mediated synovial inflammation and joint destruction in rheumatoid arthritis. Clin Exp Rheumatol, 2021, 39(1): 115-124. (IF= 4.4734)
(3)Qing-Zi Chen, Yu-Bo Zhou, Li-Fen Zhou, Zhao-Di Fu, You-Sen Wu, Yan Chen, Shu-Ni Li,Jian-Rong Huang, Jian-Hua Li*(通信). TRPC6 modulates adhesion of neutrophils to airway epithelial cells via NF- κB activation and ICAM-1 expression with ozone exposure. Experimental Cell Research, 377 (2019) 56–66. (IF=3.383)
(4)Li-Fen Zhou,Qing-Zi Chen,Chun-Tao Yang, Zhao-Di Fu, Shen-Ting Zhao, Yan Chen, Shu-Ni Li, Li Liao, Yu-Bo Zhou, Jian-Rong Huang, Jian-Hua Li*(通信). TRPC6 contributes to LPS-induced inflammation through ERK1/2 and p38 pathway in bronchial epithelial cells. Am J Physiol Cell Physiol ,2017, 117-2017. (IF= 3.454)
(5)Lei Zhao, Heng-Rui Liang, Feng-Ying Chen, Zi Chen, Wei-Jie Guan and Jian-Hua Li*(通信). Association between air pollution and cardiovascular mortality in China: a systematic review and meta-analysis. Oncotarget. 2017 , 8 (39) :66438-66448.
(6)Yan Chen, Wandan Huang, Feiyu Chen, Guoping Hu, Fenglei Li, Jian-Hua Li*(通信), Aiguo Xuan. Pregnane X receptors regulate CYP2C8 and P-glycoprotein to impact on the resistance of NSCLC cells to Taxol. Cancer Med. 2016 Dec; 5(12):3564-3571.(IF=3.362)
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